Common symptoms: nodules, erythematous nodules of the lower extremities, erythematous nodules, lymphadenopathy, papules, subcutaneous nodules, patchy sarcomas
Sarcoidosis is a generalized granulomatous disease involving the skin and many internal organs. In addition to the skin, the affected areas include the lungs, mediastinum and surrounding lymph nodes, phalanges, myocardium, central nervous system, liver, spleen, kidney, eyes and parotid glands. Sarcoidosis may involve only one organ or tissue or may involve multiple organs or tissues simultaneously. The disease progresses slowly, alternating with remission and relapse. The clinical symptoms of this disease are varied.
1. The skin with sarcoidosis is usually papules, nodules, plaques, erythroderma, psoriasis-like lesions, scarring sarcomas, hypopigmentation, and alopecia. Skin lesions are asymmetrically distributed on the face and extremities. The rash is hard and elastic at the touch, gradually spreading under the skin and covering the entire thickness of the dermis. The change of epidermis is not obvious, can be slightly thin, change color, Telangiectasia and a little scale. Often light red to purple-brown, not broken, no conscious symptoms.
(1) papular sarcomatous tumor, with lesions ranging from pinhead to pea-sized nodules, also known as miliary sarcomas. Mainly distributed in the face, neck and shoulder. When the slide is pressed, it shows a pale yellow spot similar to a lupus nodule. No Trace is left after the slide subsides, sometimes leaving pigment spots, atrophy and scar.
(2) this unique patchy lesion is first reported as a large lobulated nodular lesion with a slightly elevated, flattened surface, commonly seen in the cheeks, nose, and arms.
(3) psoriasis-like sarcomas often occur in well-defined patches of the trunk and limbs with psoriasis-like scales.
(4) chilblain-like lupus, in the prone parts of chilblain, such as ear pregnancy, cheeks, nose, toes symmetrically appear in the light infiltration of the bluish red or purplish red plaque.
(5) subcutaneous sarcomas, also known as Darier-Roussy sarcomas. A firm, subdermal tubercle about the size of a bean to a chestnut, adherent to the skin, with a light pansy-colored epidermis, common on the trunk, rarely seen on the face, and without conscious symptoms.
(6) keloid sarcoma. Lesions occur at the site of the scar. Such as Burns, Folliculitis, herpes zoster scars. Make original scar area expands, height increases, resemble scar a knot in one’s heart.
(7) erythrodermic sarcomas with diffuse diffuse infiltrative erythema and scaly plaques with unclear borders.
(8) Erythema nodosum sarcoidosis, in some sarcoidosis patients with multiple arthralgia accompanied by fever and increased ESR, x-ray examination of hilar lymphadenopathy. In the face, back and extensor side of limbs, there were scattered painful subcutaneous nodules. Red skin on the surface, most common in young women.
(9) mucosal sarcomas, hard palate, buccal region, uvula and large tonsillar pinhead papules in the oral cavity fuse together to form flat plaques and small nodules of palpebral conjunctiva and lacrimal gland.
(10) for other skin lesions, sarcoidosis may be associated with subcutaneous calcinosis, urticaria, Erythema multiforme, and folliculitis. Atrophy of the skin, hyperkeratosis, hyperpigmentation or hypopigmentation can also be caused by this disease.
2. Other organ damage, sarcoidosis is a systemic disease, in addition to skin damage, there are many organs involved.
(1) lymphadenopathy, with 50% lymphadenopathy. The early stages of sarcoidosis are usually confined to the neck or axillary lymphadenopathy and later to the lymphadenopathy, especially the mediastinum and hilum lymphadenopathy.
(2)25% ~ 30% of eyes suffered from ocular sarcoidosis, iritis and Uveitis. The most common is granulomatous nodules of the iris. The lacrimal gland is involved with painless nodular swelling, lacrimal gland lesions are often associated with Cervical lymphadenopathy, submandibular, salivary, and parotid glands are also involved (Mikulicz syndrome) . May also have conjunctivitis, keratitis, retinitis and optic nerve damage, cause blindness.
(3) lung damage, lung involvement is more common. The X-ray examination showed spot, strip, or Flake Shadows. Hilar lymphadenopathy. The early clinical symptom is light, but the silk examination is very obvious, and the late pulmonary fibrosis is obvious.
(4) bone joint, phalangeal joint swelling, pain, x-ray examination can have cavernous cavity, these cyst-like lesions are mostly composed of epithelioid cells, and skin lesions similar.
(5) liver involvement in about 20% of patients. The main manifestations were hepatic nodules, hepatomegaly, increased serum Alkaline phosphatase, biliary cirrhosis, and portal hypertension.
(6) the heart, often tachycardia, arrhythmia, atrioventricular block, pulmonary hypertension and heart failure.
(7) kidney, as a result of blood calcium, urine calcium increases kidney stones or sarcoid angiocytic nephritis, leading to kidney failure.
(8) damage to the nervous system, central and peripheral nerves.
Account not verified