toxic side effect
1. vitamin E has anticoagulant activity, long-term ingestion of large doses may increase the hemorrhagic stroke risk
2. Intake of low-dose vitamin E has an antioxidant effect, but may no longer have antioxidant activity when ingested in large doses. At this time, vitamin E has become a pro-oxidant.
3. Intake of large doses of vitamin E can hinder the absorption and function of other fat-soluble vitamins .
Need to know
1. Vitamin E should be stored away from light.
2. Taking vitamin E capsules can cure some women's bleeding or menorrhagia after placing the birth control ring .
3, the above daily doses of vitamin E300 mg, can make the body immune function decline in vivo T lymphocytes , B cells and mononuclear - phagocytic system dysfunction, which tends to various diseases. The Netherlands conducted a two-year survey in which researchers divided more than 600 healthy elderly people over 60 into two groups, one group taking vitamin E and the other taking placebo or sugar pills . During the study period, the incidence of respiratory infections in the two groups of elderly people was 68% and 67%, respectively. Among them, the elderly who took vitamin E were sick for about 19 days, fever accounted for 37%, and infection symptoms were more and more serious. The elderly who took placebo or sugar pills were sick for about 14 days, and fever accounted for 25%. This shows that the elderly who take vitamin E are more likely to have fever when they have respiratory infections, and the course of the disease is longer and more serious.
4, or more daily doses of vitamin E400 mg, headaches occur, dizziness, nausea, blurred vision and excessive menstruation or amenorrhea , or even because of platelet aggregation caused by thrombophlebitis and pulmonary embolism . This is particularly important for the elderly, because pulmonary embolism will cause edema and atelectasis in the area near the embolism , affect the diffusion function, reduce the partial pressure of arterial blood oxygen, especially before the embolism, there is pulmonary heart disease, or there is pulmonary vascular resistance In abnormal elderly people, less embolism can cause pulmonary hypertension , which can lead to complications such as heart failure .
5. After taking more than 800 mg of vitamin E daily and continuously using it for 3 weeks. Appears creatine in urine and serum creatine kinase activity is increased, it can hypertensive disease condition, angina, diabetes exacerbation.
6. Reproductive dysfunction may occur when taking vitamin E2000 to 12000 mg daily.
It can be seen that although vitamin E is one of the essential nutrients for life, long-term use still needs to be carried out under the guidance of a doctor or nutritionist to minimize side effects.
Excess reaction
American medical expert Robert has offered advice: Long-term use of large doses of vitamin E can cause various diseases. The more serious ones are: thrombophlebitis or pulmonary embolism, or both occur at the same time, this is because high doses of vitamin E can cause platelet aggregation and formation; blood pressure rises, blood pressure can be reduced or returned to normal after stopping the drug; men and women breast enlargement can occur, headache, dizziness, vertigo, blurred vision, muscle weakness, skin cracking exclusion, cheilitis, angular stomatitis , urticaria ; diabetes or angina symptoms worse; hormone metabolism, prothrombin reduced; blood cholesterol And the level of triglycerides increased; platelets increased and vitality increased and immune function decreased.
Adults take relatively large doses of vitamin E (d-α-tocopherol 400~800mg/d) for many years without any obvious damage. People who take 800~3200mg/d will occasionally experience muscle weakness, fatigue, vomiting and diarrhea . The most obvious toxic effect when vitamin E>1000mg/d is to antagonize the action of vitamin K and enhance oral coumarin anticoagulant This can cause significant bleeding.
Contraindications
When vitamin E is used with the following five drugs at the same time, it must be carried out under the guidance of a doctor. Do not take it by yourself.
Aspirin : Both vitamin E and aspirin can reduce blood viscosity, so when vitamin E and aspirin are taken at the same time, the doctor should adjust the patient's dosage according to the specific situation.
Vitamin K : Vitamin E has an antagonistic effect on vitamin K, and can inhibit platelet aggregation and reduce blood coagulation. Therefore, please do not take vitamin E at the same time before surgery or when taking anticoagulant drugs.
Digitalis : Vitamin E can enhance the heart strengthening effect of digitalis . Patients who use such drugs should use vitamin E with caution to avoid digitalis poisoning .
Neomycin : Drugs that affect absorption, such as neomycin, will affect the body's absorption of vitamin E, so taking them at the same time may reduce the effects of both drugs .
Estrogen : Long-term high-dose (more than 400mg per day) taking vitamin E, especially in combination with estrogen, can induce thrombophlebitis, so be vigilant.
In addition, if vitamin E is taken with warfarin (a blood coagulant) at the same time, it will increase the possibility of abnormal bleeding. A cholesterol-lowering drug called a bile acid chelator (such as colestipol and cholestyramine) reduces the absorption of vitamin E. Vitamin E interacts with cyclosporine (a drug to treat cancer), reducing the effectiveness of both.
Compatibility taboo
Tocopherol is compatible with peroxides and metal ions, especially iron, copper and silver ions. Tocopherol can be absorbed by plastic.
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